Antibodies, Assay Kits, Bap1 Antibody, cDNA, Culture Cells, Devices, DNA, DNA Templates, DNA Testing, E coli, EIA, EIA electrophoresis, Eif2A Antibody, Elisa Kits, Enzymes, Exosomes, Fto Antibody, Glut2 Antibody, Gsk3 Alpha, Hama Antibodies, Laminin Alpha 5, Muc2 Antibody, Nedd4 Antibody, Nox1 Antibody, Particles, Pcr Kits, Percp, peroxidase, Pkr Antibody, plex, precipitation, Preps, Primary Antibodies, profiling, Pure, Purification, purified, Reagents, Real-time, Recombinant Proteins, Rhesus, RNA, Vector & Virus, Western Blot, Zebrafish Antibodies
Common Denominators in the Immunobiology of IgG4 Autoimmune Diseases: What Do Glomerulonephritis, Pemphigus Vulgaris, Myasthenia Gravis, Thrombotic Thrombocytopenic Purpura and Autoimmune Encephalitis Have in Common?
IgG4 autoimmune ailments (IgG4-AID) are an rising group of autoimmune ailments which might be attributable to pathogenic autoantibodies of the IgG4 subclass. It has solely not too long ago been appreciated, that members of this group share related immunobiological and therapeutic features though completely different antigens, tissues and organs are affected: glomerulonephritis (kidney), pemphigus vulgaris (pores and skin), thrombotic thrombocytopenic purpura (hematologic system) muscle-specific kinase (MuSK) in myasthenia gravis (peripheral nervous system) and autoimmune encephalitis (central nervous system) to present some examples.
In all these ailments, sufferers’ IgG4 subclass autoantibodies block protein-protein interactions as a substitute of inflicting complement mediated tissue damage, sufferers reply favorably to rituximab and share a genetic predisposition: no less than 5 HLA class II genes have been reported in particular person research to be related to a number of completely different IgG4-AID.
This means a task for the HLA class II area and particularly the DRβ1 chain for aberrant priming of autoreactive T-cells towards a power immune response skewed towards the manufacturing of IgG4 subclass autoantibodies. The goal of this overview is to offer an replace on findings arguing for a typical pathogenic mechanism in IgG4-AID basically and to offer hypotheses in regards to the function of distinct HLA haplotypes, T-cells and cytokines in IgG4-AID.
Immunobiology and Software of Aloe Vera-Primarily based Scaffolds in Tissue Engineering
Aloe vera (AV), a succulent plant belonging to the Liliaceae household, has been broadly used for biomedical and pharmaceutical utility. Its reputation stems from a number of of its bioactive elements which have anti-oxidant, anti-microbial, anti-inflammatory and even immunomodulatory results. Given such distinctive multi-modal organic influence, AV has been thought of as a biomaterial for regenerative medication and tissue engineering functions, the place tissue restore and neo-angiogenesis are important.
- This overview outlines the rising scientific proof that demonstrates the benefit of AV as tissue engineering scaffolds. We significantly spotlight the latest advances within the utility of AV-based scaffolds.
- From a tissue engineering perspective, it’s pivotal that the implanted scaffolds strike an acceptable overseas physique response to be well-accepted within the physique with out problems.
- Herein, we spotlight the important thing mobile processes that regulate the overseas physique response to implanted scaffolds and underline the immunomodulatory results incurred by AV on the innate and adaptive system.
- Provided that AV has a number of useful elements, we talk about the significance of delving deeper into uncovering its motion mechanism and thereby enhancing materials design methods for higher tissue engineering constructs for biomedical functions.
Editorial: Immunobiology of Tick-Host-Pathogen Interactions
This particular difficulty of Parasite Immunology focuses on the scope of immune interactions that happen inside the triad of ticks, their vertebrate hosts, and tick-borne pathogens. Ticks and tick-borne infections are world medical and veterinary public well being threats resulting from higher abundance and increasing geographic ranges of tick vectors; introduction of tick transmitted ailments into new areas; rising pathogens, and, rising incidence of tick-borne infectious ailments.
Immunobiology and immunotherapy of HCC: highlight on innate and innate-like immune cells
Immune-based therapies akin to immune checkpoint inhibitors have revolutionized the systemic therapy of varied most cancers sorts. The therapeutic utility of monoclonal antibodies focusing on inhibitory pathways akin to programmed cell death-1(PD-1)/programmed cell dying ligand 1 (PD-L1) and CTLA-Four to cells of the adaptive immune system has not too long ago been proven to generate significant enchancment within the medical end result of hepatocellular carcinoma (HCC).
However, present immunotherapeutic approaches induce sturdy responses in solely a subset of HCC sufferers. Since immunologic mechanisms akin to power irritation resulting from power viral hepatitis or alcoholic and nonalcoholic fatty liver illness play an important function in the initiation, growth, and development of HCC, it is very important perceive the underlying mechanisms shaping the distinctive tumor microenvironment of liver most cancers.
The liver is an immunologic organ with giant populations of innate and innate-like immune cells and is uncovered to bacterial, viral, and fungal antigens via the gut-liver axis. Right here, we summarize and spotlight the function of those cells in liver most cancers and suggest methods to therapeutically goal them. We additionally talk about present immunotherapeutic methods in HCC and description latest advances in our understanding of how the therapeutic potential of those brokers is perhaps enhanced.
) Guanidine Thiocyanate (Molecular Biology Grade) |
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| CE166 | GeneOn | 1 kg | EUR 256 |
) Tris - Hydrochloride (Molecular Biology Grade) |
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| CE234 | GeneOn | 250 g | EUR 83 |
Tris - Hydrochloride (Molecular Biology Grade) |
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| CE235 | GeneOn | 500 g | EUR 120 |
Tris - Hydrochloride (Molecular Biology Grade) |
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| CE236 | GeneOn | 1 kg | EUR 186 |
 Guanidine hydrochloride |
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| GB0242 | Bio Basic | 100g | EUR 67.4 |
) Guanidine (hydrochloride) |
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| HY-B0178A | MedChemExpress | 50g | EUR 133 |
 Urea, suitable for molecular biology |
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| GE1210-1KG | Glentham Life Sciences | 1 kg | EUR 89 |
Urea, suitable for molecular biology |
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| GE1210-500G | Glentham Life Sciences | 500 g | EUR 64 |
 Guanidine hydrochloride, 99% |
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| GE1914-100G | Glentham Life Sciences | 100 g | EUR 46 |
Guanidine hydrochloride, 99% |
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| GE1914-250G | Glentham Life Sciences | 250 g | EUR 54 |
Guanidine hydrochloride, 99% |
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| GE1914-25G | Glentham Life Sciences | 25 g | EUR 42 |
Guanidine hydrochloride, 99% |
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| GE1914-1KG | Glentham Life Sciences | 1 kg | EUR 110 |
Guanidine hydrochloride, 99% |
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| GE1914-500G | Glentham Life Sciences | 500 g | EUR 74 |
 Sucrose, GlenBiol, suitable for molecular biology |
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| GC3201-1KG | Glentham Life Sciences | 1 kg | EUR 75 |
) BCIP (Molecular Biology Grade) |
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| CE108 | GeneOn | 250 mg | EUR 63 |
BCIP (Molecular Biology Grade) |
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| CE109 | GeneOn | 1 g | EUR 90 |
) CHAPS (Molecular Biology Grade) |
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| CE114 | GeneOn | 1 g | EUR 55 |
CHAPS (Molecular Biology Grade) |
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| CE115 | GeneOn | 5 g | EUR 131 |
CHAPS (Molecular Biology Grade) |
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| CE116 | GeneOn | 25 g | EUR 410 |
) DAPI (Molecular Biology Grade) |
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| CE117 | GeneOn | 5 mg | EUR 60 |
DAPI (Molecular Biology Grade) |
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| CE118 | GeneOn | 25 mg | EUR 133 |
DAPI (Molecular Biology Grade) |
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| CE119 | GeneOn | 100 mg | EUR 319 |
) Dimethylsulfoxide (Molecular Biology Grade) |
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| CE120 | GeneOn | 100 ml | EUR 55 |
Dimethylsulfoxide (Molecular Biology Grade) |
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| CE121 | GeneOn | 500 ml | EUR 92 |
) DTT (Molecular Biology Grade) |
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| CE131 | GeneOn | 5 g | EUR 78 |
DTT (Molecular Biology Grade) |
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| CE132 | GeneOn | 10 g | EUR 111 |
DTT (Molecular Biology Grade) |
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| CE133 | GeneOn | 25 g | EUR 203 |
) Glycine (Molecular Biology Grade) |
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| CE158 | GeneOn | 1 kg | EUR 70 |
Glycine (Molecular Biology Grade) |
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| CE159 | GeneOn | 5 kg | EUR 190 |
) HEPES (Molecular Biology Grade) |
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| CE171 | GeneOn | 100 g | EUR 82 |
HEPES (Molecular Biology Grade) |
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| CE172 | GeneOn | 500 g | EUR 224 |
HEPES (Molecular Biology Grade) |
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| CE173 | GeneOn | 1 kg | EUR 354 |
) Lysozyme (Molecular Biology Grade) |
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| CE188 | GeneOn | 1 g | EUR 59 |
Lysozyme (Molecular Biology Grade) |
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| CE189 | GeneOn | 10 g | EUR 206 |
) NAD (Molecular Biology Grade) |
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| CE196 | GeneOn | 1 g | EUR 60 |
NAD (Molecular Biology Grade) |
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| CE197 | GeneOn | 5 g | EUR 138 |
) NBT (Molecular Biology Grade) |
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| CE209 | GeneOn | 1 g | EUR 103 |
NBT (Molecular Biology Grade) |
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| CE210 | GeneOn | 5 g | EUR 300 |
) Tris (Molecular Biology Grade) |
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| CE237 | GeneOn | 500 g | EUR 89 |
Tris (Molecular Biology Grade) |
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| CE238 | GeneOn | 1 kg | EUR 128 |
Tris (Molecular Biology Grade) |
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| CE239 | GeneOn | 5 kg | EUR 446 |
) Tween20 (Molecular Biology Grade) |
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| CE242 | GeneOn | 1 l | EUR 89 |
) Water (Molecular Biology Grade) |
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| CE243 | GeneOn | 500 ml | EUR 52 |
Water (Molecular Biology Grade) |
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| CE244 | GeneOn | 1 l | EUR 56 |
) Ammonium sulfate (Molecular Biology Grade) |
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| CE105 | GeneOn | 250 g | EUR 46 |
Ammonium sulfate (Molecular Biology Grade) |
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| CE106 | GeneOn | 1 kg | EUR 60 |
Ammonium sulfate (Molecular Biology Grade) |
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| CE107 | GeneOn | 5 kg | EUR 128 |
) Bis-Acrylamid (Molecular Biology Grade) |
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| CE110 | GeneOn | 50 g | EUR 79 |
Bis-Acrylamid (Molecular Biology Grade) |
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| CE111 | GeneOn | 250 g | EUR 216 |
) Formamide deionized (Molecular Biology Grade) |
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| CE145 | GeneOn | 500 ml | EUR 73 |
Formamide deionized (Molecular Biology Grade) |
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| CE146 | GeneOn | 1 l | EUR 100 |
) Glycerol 87 % (Molecular Biology Grade) |
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| CE154 | GeneOn | 1 l | EUR 78 |
) Glycerol waterfree (Molecular Biology Grade) |
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| CE155 | GeneOn | 500 ml | EUR 65 |
Glycerol waterfree (Molecular Biology Grade) |
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| CE156 | GeneOn | 1 l | EUR 85 |
Glycerol waterfree (Molecular Biology Grade) |
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| CE157 | GeneOn | 2.5 l | EUR 142 |
) Urea Crystalline (Molecular Biology Grade) |
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| CE167 | GeneOn | 1 kg | EUR 60 |
Urea Crystalline (Molecular Biology Grade) |
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| CE168 | GeneOn | 5 kg | EUR 151 |
) MOPS buffer (Molecular Biology Grade) |
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| CE194 | GeneOn | 100 g | EUR 85 |
MOPS buffer (Molecular Biology Grade) |
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| CE195 | GeneOn | 250 g | EUR 141 |
) Sodium chloride (Molecular Biology Grade) |
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| CE205 | GeneOn | 500 g | EUR 52 |
Sodium chloride (Molecular Biology Grade) |
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| CE206 | GeneOn | 1 kg | EUR 59 |
Sodium chloride (Molecular Biology Grade) |
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| CE207 | GeneOn | 5 kg | EUR 103 |
-Sucrose (Molecular Biology Grade)) D(+)-Sucrose (Molecular Biology Grade) |
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| CE224 | GeneOn | 500 g | EUR 56 |
D(+)-Sucrose (Molecular Biology Grade) |
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| CE225 | GeneOn | 1 kg | EUR 70 |
D(+)-Sucrose (Molecular Biology Grade) |
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| CE226 | GeneOn | 5 kg | EUR 173 |
) TritonX-100 (Molecular Biology Grade) |
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| CE240 | GeneOn | 500 ml | EUR 56 |
TritonX-100 (Molecular Biology Grade) |
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| CE241 | GeneOn | 1 l | EUR 66 |
 Tween 20, Molecular Biology Grade |
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| T9100-010 | GenDepot | 100ml | EUR 72 |
Tween 20, Molecular Biology Grade |
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| T9100-050 | GenDepot | 500ml | EUR 111 |
Tween 20, Molecular Biology Grade |
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| T9100-100 | GenDepot | 1L | EUR 134 |
 Water, Ultrapure Molecular Biology Grade |
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| 41024-4L | Biotium | 4L | EUR 121 |
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Description: Minimum order quantity: 1 unit of 4L |
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 Double distilled for Molecular Biology) Phenol, (Carbolic acid) Double distilled for Molecular Biology |
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| PD0252 | Bio Basic | 500g | EUR 160.49 |
 Agarose, low EEO, GlenBiol, suitable for molecular biology |
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| GE6258-100G | Glentham Life Sciences | 100 g | EUR 181 |
 Water, distilled, GlenBiol™, suitable for molecular biology |
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| GK8512-1L | Glentham Life Sciences | 1 l | EUR 77 |
 solution) Guanidine hydrochloride (6 M) solution |
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| B1013-1L | Biovision | EUR 251 | |
Guanidine hydrochloride (6 M) solution |
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| B1013-4L | Biovision | EUR 588 | |
) EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE135 | GeneOn | 250 g | EUR 60 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE136 | GeneOn | 500 g | EUR 72 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE137 | GeneOn | 1 kg | EUR 104 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE138 | GeneOn | 5 kg | EUR 349 |
-Glucose waterfree (Molecular Biology Grade)) D(+)-Glucose waterfree (Molecular Biology Grade) |
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| CE148 | GeneOn | 500 g | EUR 56 |
D(+)-Glucose waterfree (Molecular Biology Grade) |
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| CE149 | GeneOn | 1 kg | EUR 63 |
D(+)-Glucose waterfree (Molecular Biology Grade) |
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| CE150 | GeneOn | 5 kg | EUR 150 |
) Yeast extract powder (Molecular Biology Grade) |
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| CE169 | GeneOn | 500 g | EUR 111 |
) Hyaluronidase Grade I (Molecular Biology Grade) |
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| CE174 | GeneOn | 1 g | EUR 194 |
Hyaluronidase Grade I (Molecular Biology Grade) |
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| CE175 | GeneOn | 5 g | EUR 767 |
) Magnesium acetate - Tetrahydrate (Molecular Biology Grade) |
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| CE190 | GeneOn | 500 g | EUR 82 |
) NADH - Disodium salt (Molecular Biology Grade) |
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| CE198 | GeneOn | 1 g | EUR 76 |
NADH - Disodium salt (Molecular Biology Grade) |
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| CE199 | GeneOn | 5 g | EUR 204 |
) NADP - sodium salt (Molecular Biology Grade) |
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| CE200 | GeneOn | 250 mg | EUR 77 |
NADP - sodium salt (Molecular Biology Grade) |
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| CE201 | GeneOn | 1 g | EUR 159 |
) NADPH - Tetrasodium salt (Molecular Biology Grade) |
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| CE202 | GeneOn | 25 mg | EUR 59 |
NADPH - Tetrasodium salt (Molecular Biology Grade) |
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| CE203 | GeneOn | 100 mg | EUR 105 |
NADPH - Tetrasodium salt (Molecular Biology Grade) |
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| CE204 | GeneOn | 500 mg | EUR 312 |
 (Molecular Biology Grade)) SSC Buffer (20X) (Molecular Biology Grade) |
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| CE229 | GeneOn | 1 l | EUR 72 |