Antibodies, Assay Kits, Bap1 Antibody, cDNA, Culture Cells, Devices, DNA, DNA Templates, DNA Testing, E coli, EIA, EIA electrophoresis, Eif2A Antibody, Elisa Kits, Enzymes, Exosomes, Fto Antibody, Glut2 Antibody, Gsk3 Alpha, Hama Antibodies, Laminin Alpha 5, Muc2 Antibody, Nedd4 Antibody, Nox1 Antibody, Particles, Pcr Kits, Percp, peroxidase, Pkr Antibody, plex, precipitation, Preps, Primary Antibodies, profiling, Pure, Purification, purified, Reagents, Real-time, Recombinant Proteins, Rhesus, RNA, Vector & Virus, Western Blot, Zebrafish Antibodies
Common Denominators in the Immunobiology of IgG4 Autoimmune Diseases: What Do Glomerulonephritis, Pemphigus Vulgaris, Myasthenia Gravis, Thrombotic Thrombocytopenic Purpura and Autoimmune Encephalitis Have in Common?
IgG4 autoimmune ailments (IgG4-AID) are an rising group of autoimmune ailments which might be attributable to pathogenic autoantibodies of the IgG4 subclass. It has solely not too long ago been appreciated, that members of this group share related immunobiological and therapeutic features though completely different antigens, tissues and organs are affected: glomerulonephritis (kidney), pemphigus vulgaris (pores and skin), thrombotic thrombocytopenic purpura (hematologic system) muscle-specific kinase (MuSK) in myasthenia gravis (peripheral nervous system) and autoimmune encephalitis (central nervous system) to present some examples.
In all these ailments, sufferers’ IgG4 subclass autoantibodies block protein-protein interactions as a substitute of inflicting complement mediated tissue damage, sufferers reply favorably to rituximab and share a genetic predisposition: no less than 5 HLA class II genes have been reported in particular person research to be related to a number of completely different IgG4-AID.
This means a task for the HLA class II area and particularly the DRβ1 chain for aberrant priming of autoreactive T-cells towards a power immune response skewed towards the manufacturing of IgG4 subclass autoantibodies. The goal of this overview is to offer an replace on findings arguing for a typical pathogenic mechanism in IgG4-AID basically and to offer hypotheses in regards to the function of distinct HLA haplotypes, T-cells and cytokines in IgG4-AID.
Immunobiology and Software of Aloe Vera-Primarily based Scaffolds in Tissue Engineering
Aloe vera (AV), a succulent plant belonging to the Liliaceae household, has been broadly used for biomedical and pharmaceutical utility. Its reputation stems from a number of of its bioactive elements which have anti-oxidant, anti-microbial, anti-inflammatory and even immunomodulatory results. Given such distinctive multi-modal organic influence, AV has been thought of as a biomaterial for regenerative medication and tissue engineering functions, the place tissue restore and neo-angiogenesis are important.
- This overview outlines the rising scientific proof that demonstrates the benefit of AV as tissue engineering scaffolds. We significantly spotlight the latest advances within the utility of AV-based scaffolds.
- From a tissue engineering perspective, it’s pivotal that the implanted scaffolds strike an acceptable overseas physique response to be well-accepted within the physique with out problems.
- Herein, we spotlight the important thing mobile processes that regulate the overseas physique response to implanted scaffolds and underline the immunomodulatory results incurred by AV on the innate and adaptive system.
- Provided that AV has a number of useful elements, we talk about the significance of delving deeper into uncovering its motion mechanism and thereby enhancing materials design methods for higher tissue engineering constructs for biomedical functions.
Editorial: Immunobiology of Tick-Host-Pathogen Interactions
This particular difficulty of Parasite Immunology focuses on the scope of immune interactions that happen inside the triad of ticks, their vertebrate hosts, and tick-borne pathogens. Ticks and tick-borne infections are world medical and veterinary public well being threats resulting from higher abundance and increasing geographic ranges of tick vectors; introduction of tick transmitted ailments into new areas; rising pathogens, and, rising incidence of tick-borne infectious ailments.
Immunobiology and immunotherapy of HCC: highlight on innate and innate-like immune cells
Immune-based therapies akin to immune checkpoint inhibitors have revolutionized the systemic therapy of varied most cancers sorts. The therapeutic utility of monoclonal antibodies focusing on inhibitory pathways akin to programmed cell death-1(PD-1)/programmed cell dying ligand 1 (PD-L1) and CTLA-Four to cells of the adaptive immune system has not too long ago been proven to generate significant enchancment within the medical end result of hepatocellular carcinoma (HCC).
However, present immunotherapeutic approaches induce sturdy responses in solely a subset of HCC sufferers. Since immunologic mechanisms akin to power irritation resulting from power viral hepatitis or alcoholic and nonalcoholic fatty liver illness play an important function in the initiation, growth, and development of HCC, it is very important perceive the underlying mechanisms shaping the distinctive tumor microenvironment of liver most cancers.
The liver is an immunologic organ with giant populations of innate and innate-like immune cells and is uncovered to bacterial, viral, and fungal antigens via the gut-liver axis. Right here, we summarize and spotlight the function of those cells in liver most cancers and suggest methods to therapeutically goal them. We additionally talk about present immunotherapeutic methods in HCC and description latest advances in our understanding of how the therapeutic potential of those brokers is perhaps enhanced.
) Guanidine Thiocyanate (Molecular Biology Grade) |
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| CE166 | GeneOn | 1 kg | EUR 307.2 |
) Tris - Hydrochloride (Molecular Biology Grade) |
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| CE234 | GeneOn | 250 g | EUR 99.6 |
Tris - Hydrochloride (Molecular Biology Grade) |
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| CE235 | GeneOn | 500 g | EUR 144 |
Tris - Hydrochloride (Molecular Biology Grade) |
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| CE236 | GeneOn | 1 kg | EUR 223.2 |
) Guanidine (hydrochloride) |
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| HY-B0178A | MedChemExpress | 50g | EUR 159.6 |
 Guanidine hydrochloride |
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| GB0242 | Bio Basic | 100g | EUR 80.88 |
 Urea, suitable for molecular biology |
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| GE1210-1KG | Glentham Life Sciences | 1 kg | EUR 106.8 |
Urea, suitable for molecular biology |
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| GE1210-500G | Glentham Life Sciences | 500 g | EUR 76.8 |
 Guanidine hydrochloride, 99% |
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| GE1914-100G | Glentham Life Sciences | 100 g | EUR 55.2 |
Guanidine hydrochloride, 99% |
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| GE1914-1KG | Glentham Life Sciences | 1 kg | EUR 132 |
Guanidine hydrochloride, 99% |
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| GE1914-250G | Glentham Life Sciences | 250 g | EUR 64.8 |
Guanidine hydrochloride, 99% |
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| GE1914-25G | Glentham Life Sciences | 25 g | EUR 50.4 |
Guanidine hydrochloride, 99% |
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| GE1914-500G | Glentham Life Sciences | 500 g | EUR 88.8 |
 Sucrose, GlenBiol, suitable for molecular biology |
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| GC3201-1KG | Glentham Life Sciences | 1 kg | EUR 90 |
) BCIP (Molecular Biology Grade) |
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| CE108 | GeneOn | 250 mg | EUR 75.6 |
BCIP (Molecular Biology Grade) |
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| CE109 | GeneOn | 1 g | EUR 108 |
) CHAPS (Molecular Biology Grade) |
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| CE114 | GeneOn | 1 g | EUR 66 |
CHAPS (Molecular Biology Grade) |
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| CE115 | GeneOn | 5 g | EUR 157.2 |
CHAPS (Molecular Biology Grade) |
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| CE116 | GeneOn | 25 g | EUR 492 |
) DAPI (Molecular Biology Grade) |
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| CE117 | GeneOn | 5 mg | EUR 72 |
DAPI (Molecular Biology Grade) |
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| CE118 | GeneOn | 25 mg | EUR 159.6 |
DAPI (Molecular Biology Grade) |
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| CE119 | GeneOn | 100 mg | EUR 382.8 |
) Dimethylsulfoxide (Molecular Biology Grade) |
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| CE120 | GeneOn | 100 ml | EUR 66 |
Dimethylsulfoxide (Molecular Biology Grade) |
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| CE121 | GeneOn | 500 ml | EUR 110.4 |
) DTT (Molecular Biology Grade) |
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| CE131 | GeneOn | 5 g | EUR 93.6 |
DTT (Molecular Biology Grade) |
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| CE132 | GeneOn | 10 g | EUR 133.2 |
DTT (Molecular Biology Grade) |
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| CE133 | GeneOn | 25 g | EUR 243.6 |
) Glycine (Molecular Biology Grade) |
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| CE158 | GeneOn | 1 kg | EUR 84 |
Glycine (Molecular Biology Grade) |
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| CE159 | GeneOn | 5 kg | EUR 228 |
) HEPES (Molecular Biology Grade) |
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| CE171 | GeneOn | 100 g | EUR 98.4 |
HEPES (Molecular Biology Grade) |
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| CE172 | GeneOn | 500 g | EUR 268.8 |
HEPES (Molecular Biology Grade) |
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| CE173 | GeneOn | 1 kg | EUR 424.8 |
) Lysozyme (Molecular Biology Grade) |
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| CE188 | GeneOn | 1 g | EUR 70.8 |
Lysozyme (Molecular Biology Grade) |
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| CE189 | GeneOn | 10 g | EUR 247.2 |
) NAD (Molecular Biology Grade) |
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| CE196 | GeneOn | 1 g | EUR 72 |
NAD (Molecular Biology Grade) |
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| CE197 | GeneOn | 5 g | EUR 165.6 |
) NBT (Molecular Biology Grade) |
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| CE209 | GeneOn | 1 g | EUR 123.6 |
NBT (Molecular Biology Grade) |
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| CE210 | GeneOn | 5 g | EUR 360 |
) Tris (Molecular Biology Grade) |
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| CE237 | GeneOn | 500 g | EUR 106.8 |
Tris (Molecular Biology Grade) |
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| CE238 | GeneOn | 1 kg | EUR 153.6 |
Tris (Molecular Biology Grade) |
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| CE239 | GeneOn | 5 kg | EUR 535.2 |
) Tween20 (Molecular Biology Grade) |
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| CE242 | GeneOn | 1 l | EUR 106.8 |
) Water (Molecular Biology Grade) |
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| CE243 | GeneOn | 500 ml | EUR 62.4 |
Water (Molecular Biology Grade) |
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| CE244 | GeneOn | 1 l | EUR 67.2 |
 100mL Molecular Biology Grade |
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| 46-000-CI | Scientific Laboratory Supplies | PK6 | EUR 70.68 |
 500mL Molecular Biology Grade |
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| 46-000-CV | Scientific Laboratory Supplies | PK6 | EUR 124.26 |
 Water, Ultrapure Molecular Biology Grade |
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| 41024-4L | Biotium | 4L | EUR 145.2 |
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Description: Minimum order quantity: 1 unit of 4L |
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) Ammonium sulfate (Molecular Biology Grade) |
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| CE105 | GeneOn | 250 g | EUR 55.2 |
Ammonium sulfate (Molecular Biology Grade) |
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| CE106 | GeneOn | 1 kg | EUR 72 |
Ammonium sulfate (Molecular Biology Grade) |
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| CE107 | GeneOn | 5 kg | EUR 153.6 |
) Bis-Acrylamid (Molecular Biology Grade) |
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| CE110 | GeneOn | 50 g | EUR 94.8 |
Bis-Acrylamid (Molecular Biology Grade) |
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| CE111 | GeneOn | 250 g | EUR 259.2 |
) Formamide deionized (Molecular Biology Grade) |
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| CE145 | GeneOn | 500 ml | EUR 87.6 |
Formamide deionized (Molecular Biology Grade) |
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| CE146 | GeneOn | 1 l | EUR 120 |
) Glycerol 87 % (Molecular Biology Grade) |
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| CE154 | GeneOn | 1 l | EUR 93.6 |
) Glycerol waterfree (Molecular Biology Grade) |
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| CE155 | GeneOn | 500 ml | EUR 78 |
Glycerol waterfree (Molecular Biology Grade) |
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| CE156 | GeneOn | 1 l | EUR 102 |
Glycerol waterfree (Molecular Biology Grade) |
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| CE157 | GeneOn | 2.5 l | EUR 170.4 |
) Urea Crystalline (Molecular Biology Grade) |
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| CE167 | GeneOn | 1 kg | EUR 72 |
Urea Crystalline (Molecular Biology Grade) |
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| CE168 | GeneOn | 5 kg | EUR 181.2 |
) MOPS buffer (Molecular Biology Grade) |
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| CE194 | GeneOn | 100 g | EUR 102 |
MOPS buffer (Molecular Biology Grade) |
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| CE195 | GeneOn | 250 g | EUR 169.2 |
) Sodium chloride (Molecular Biology Grade) |
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| CE205 | GeneOn | 500 g | EUR 62.4 |
Sodium chloride (Molecular Biology Grade) |
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| CE206 | GeneOn | 1 kg | EUR 70.8 |
Sodium chloride (Molecular Biology Grade) |
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| CE207 | GeneOn | 5 kg | EUR 123.6 |
-Sucrose (Molecular Biology Grade)) D(+)-Sucrose (Molecular Biology Grade) |
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| CE224 | GeneOn | 500 g | EUR 67.2 |
D(+)-Sucrose (Molecular Biology Grade) |
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| CE225 | GeneOn | 1 kg | EUR 84 |
D(+)-Sucrose (Molecular Biology Grade) |
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| CE226 | GeneOn | 5 kg | EUR 207.6 |
) TritonX-100 (Molecular Biology Grade) |
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| CE240 | GeneOn | 500 ml | EUR 67.2 |
TritonX-100 (Molecular Biology Grade) |
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| CE241 | GeneOn | 1 l | EUR 79.2 |
 Tween 20, Molecular Biology Grade |
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| T9100-010 | GenDepot | 100ml | EUR 86.4 |
Tween 20, Molecular Biology Grade |
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| T9100-050 | GenDepot | 500ml | EUR 133.2 |
Tween 20, Molecular Biology Grade |
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| T9100-100 | GenDepot | 1L | EUR 160.8 |
 1L Molecular Biology Grade Water |
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| 46-000-CM | Scientific Laboratory Supplies | PK6 | EUR 177.84 |
 Water, distilled, GlenBiol™, suitable for molecular biology |
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| GK8512-1L | Glentham Life Sciences | 1 l | EUR 92.4 |
 Agarose, low EEO, GlenBiol, suitable for molecular biology |
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| GE6258-100G | Glentham Life Sciences | 100 g | EUR 217.2 |
 Double distilled for Molecular Biology) Phenol, (Carbolic acid) Double distilled for Molecular Biology |
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| PD0252 | Bio Basic | 500g | EUR 192.59 |
 solution) Guanidine hydrochloride (6 M) solution |
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| B1013-1L | Biovision | EUR 301.2 | |
Guanidine hydrochloride (6 M) solution |
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| B1013-4L | Biovision | EUR 705.6 | |
) EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE135 | GeneOn | 250 g | EUR 72 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE136 | GeneOn | 500 g | EUR 86.4 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE137 | GeneOn | 1 kg | EUR 124.8 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE138 | GeneOn | 5 kg | EUR 418.8 |
-Glucose waterfree (Molecular Biology Grade)) D(+)-Glucose waterfree (Molecular Biology Grade) |
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| CE148 | GeneOn | 500 g | EUR 67.2 |
D(+)-Glucose waterfree (Molecular Biology Grade) |
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| CE149 | GeneOn | 1 kg | EUR 75.6 |
D(+)-Glucose waterfree (Molecular Biology Grade) |
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| CE150 | GeneOn | 5 kg | EUR 180 |
) Yeast extract powder (Molecular Biology Grade) |
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| CE169 | GeneOn | 500 g | EUR 133.2 |
) Hyaluronidase Grade I (Molecular Biology Grade) |
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| CE174 | GeneOn | 1 g | EUR 232.8 |
Hyaluronidase Grade I (Molecular Biology Grade) |
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| CE175 | GeneOn | 5 g | EUR 920.4 |
) Magnesium acetate - Tetrahydrate (Molecular Biology Grade) |
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| CE190 | GeneOn | 500 g | EUR 98.4 |
) NADH - Disodium salt (Molecular Biology Grade) |
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| CE198 | GeneOn | 1 g | EUR 91.2 |
NADH - Disodium salt (Molecular Biology Grade) |
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| CE199 | GeneOn | 5 g | EUR 244.8 |
) NADP - sodium salt (Molecular Biology Grade) |
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| CE200 | GeneOn | 250 mg | EUR 92.4 |
NADP - sodium salt (Molecular Biology Grade) |
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| CE201 | GeneOn | 1 g | EUR 190.8 |
) NADPH - Tetrasodium salt (Molecular Biology Grade) |
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| CE202 | GeneOn | 25 mg | EUR 70.8 |