UCLA Scientists Uncover Metabolic Molecule Accelerating Stem Cell Differentiation

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University of California, Los Angeles/Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research (BSCRC) – Researchers at the UCLA BSCRC and the Laboratory of Dr. Michael Teitell have discovered that an intermediary metabolic molecule, α-ketoglutarate, is a significant factor in accelerating the differentiation of pluripotent stem cells into specialized cell types. This study, published online in press today in the journal Cell Metabolism, displays a foundation on which future work can be focused on studying how metabolite production promotes stem cell differentiation.

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