UCLA Researchers Develop High-Throughput Delivery System for Placing Large Cargo into Cells

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Los Angeles – Technology was developed by the laboratories of Dr. Pei-Yu Chiou and Dr. Michael Teitell to deliver large objects, up to 3 microns in diameter, into a wide range of mammalian cells. In a long term collaboration between the Henry Samueli School of Engineering and Applied Science and the David Geffen School of Medicine at UCLA, the Chiou and Teitell groups developed a high-throughput platform that delivers large cargo into 10,000- 100,000 cells per minute. The multi-delivery platform system uses a laser pulse to open a re-sealable hole in the cell membrane to deliver functional nanoparticles, enzymes, antibodies, and live intracellular pathogenic bacteria into cells at a highly efficient rate, well beyond the capabilities for existing technologies in this area.
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