Nature Methods – In an interview for the Technology Feature (Volume 13, No. 1, January 2016, pp 37-40), Drs. Michael Teitell and Eric Pei-Yu Chiou described their recently invented cargo delivery systems. The nanoblade and BLAST (Biophotonic Laser-Assisted Surgery Tool) are novel platforms that can deliver large cargo up to 3 µm in diameter into cells. These technologies are being commercialized in a biotechnology start-up company, NanoCav, to provide these tools to academia and industry.